NR 3-4/2002
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Ocena okołotarczowego przepływu krwi u
chorych na jaskrę za pomocą skaningowego przepływomierza laserowego
Evaluation (Analysis) peripapillary blood flow in
glaucoma patients using scanning laser flowmetry
Maria Hanna Niżankowska1, Agnieszka Jamrozy-Witkowska1,
Magdalena Asejczyk2
1Z Katedry i Kliniki Okulistyki Akademii Medycznej we Wrocławiu
Kierownik: prof. dr hab. n. med. Maria Hanna Niżankowska
2Z Instytutu Fizyki, Grupa Optyki Fizjologicznej, Politechnika Wrocławska
Kierownik: prof. dr hab. n. med. Henryk Kasprzak |
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| Summary: |
Purpose: To evaluate capillary blood flow
and velocity in retinal peripapillary area in primary open angle glaucoma (POAG), normal
tension glaucoma (NTG), pseudoexfoliation glaucoma (PEXG) and age matched control group
(C) using scanning laser Doppler flowmetry (Heildelberg Retina Flowmeter).
Material and method: One randomly selected eye of 17 POAG patients (mean
age 59.3 ? 2.6), 18 NTG patients (mean age 56.4 ? 2.4), 17 PEXG patients (63.3 ? 2.8)
and 15 healthy subjects (mean age 55.8 ? 3.8) underwent examination with scanning laser
Doppler flowmetry. The measurements were performed at the superior and inferior temporal
peripapillary retinal area. The measured parameters were capillary blood flow and velocity
of the moving erythrocytes. Each image was analysed using the program AFFPIA. This
software calculates the hemodynamic parameter flow of each pixel. Comparison of value
obtained from patients and control participants were made using Student's t test.
Results: Scanning laser Doppler flowmetry results showed a significant
reduction in blood flow at the superior and inferior temporal peripapillary area in POAG
and NTG patients compared to control group (p<0.04). The POAG and NTG patients had also
significantly decreased velocity at the inferior temporal peripapillary retinal area
compared to control group. No statistical difference was found between blood flow and
velocity in POAG compared with NTG. When compared with the control participants, patients
with PEXG showed significant decreases in the mean blood flow at the inferior temporal
quadrant (p<0,05), while the differences in the mean flow and velocity at the superior
quadrant beetwen those groups were not statistically significant.
Conclusions: Our findings indicate a reduction in ocular blood flow at
the temporal peripapillary retinal area in patients with POAG and NTG compared to age
matched control participants. The peripapillary retinal microcirculation is not
significantly altered in patients with PEXG compare with POAG and JNC. The blood flow
parameters in the capillaries are lower in JNC retinas, the difference however is not
significant. Further clinical investigation is required having groups homogeneous with
respect to stage of glaucoma and controlled for factors known to effect perfusion
pressure. |
| Słowa kluczowe: |
jaskra, przepływ krwi przez gałkę oczną, skaningowy
przepływomierz laserowy. |
| Key words: |
glaucoma, ocular blood flow, scanning laser Doppler
flowmetry. |
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