NR 3-4/2002
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Poziom endoteliny-1 we krwi pacjentów z jaskrą
pierwotną otwartego kąta oraz jej wpływ na występowanie zmian w perymetrii statycznej
i GDx
The endothelin-1 level in blood serum of patients with
primary open angle glaucoma and its influence on the static perimetry and Gdx changes
Elżbieta Pieńkowska-Machoy1, Barbara Millo2
1Z Katedry Okulistyki z Kliniką i Zakładem Patofizjologii Narządu Wzroku
Kierownik: prof. dr hab. n. med. Danuta Karczewicz
2Z Katedry Biochemii Klinicznej i Diagnostyki Laboratoryjnej Pomorskiej
Akademii Medycznej w Szczecinie
Kierownik: prof. dr hab. n. med. Marek Naruszewicz |
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| Summary: |
Purpose: The aim of the work was to define
the relationships between the endothelin-1 level in blood serum of glaucoma patients
concerning the visual field defects and the number of nerve fibers.
Material and methods: 24 women and 14 men, aged 38-74 year ( mean 53,4
year) with primary open angle glaucoma, without any systemic diseases. The control group
consisted of 20 healthy women and men, aged 34-70 year ( mean 52,6 year). The endothelin-1
level was tested with the enzymo-immunologic method from the blood serum.The visual field
defects were examined with the Humphrey static perimetry. The nerve fibers were analized
with the Gdx apparatus.
Results: Mean value of ET-1 in blood serum were similar in both examined
groups, it was 0.51 in group of glaucoma patients and 0.54(fmol/l) in the control group.
There were no significant correlations between ET-1 level, static perimetry, GDx
parameters and age in the group of patients with POAG. The statistics significancy were
stated for ET-1 level and MD-parameter in static perimetry (p<0,03) and ET-1 level with
The Number - the GDx parameter (p<0,03).
Conclusion: There was no significant level of ET-1 in blood serum in
group of patients with POAG. There have not been stated any relationships between the
static perimetry and GDx changes in patients with POAG to endothelin-1 level in blood
serum. It is the preliminary communication. |
| Słowa kluczowe: |
jaskra, endotelina-1, perymetria statyczna, GDx |
| Key words: |
glaucoma, endothelin-1, static perimetry, GDx. |
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