NR 3-4/2002
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Poziom przeciwciał przeciwsiatkówkowych w
surowicy a nasilenie objawów endogennego zapalenia tylnego odcinka błony naczyniowej
Serum antiretinal antibodies and intensity of
endogenous posterior uveitis
Agnieszka Kubicka-Trz±ska
Z Katedry i Kliniki Okulistyki Collegium Medicum Uniwersytetu Jagiellońskiego
Kierownik: prof. dr hab. n. med. Maria Starzycka |
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| Summary: |
Purpose: To analyse the correlation between
the antiretinal antibodies (ARA) and intensity of intraocular inflammation in patients
with endogenous posterior uveitis.
Material and methods: 50 patients - 29 women (58%) and 21 men (42%) in
age 15-70 yrs with idiopathic posterior uveitis were examined. Intraocular inflammation
intensity was scored on standard uveitis grading system prepared by BenEzra et al. In all
cases the ARA were determined by indirect immunofluorescence test on normal monkey retina
as a substrate and FITC -labelled goat's anti-human IgA, G, M serum (Euroimmun-Germany).
The control serum was obtained from 50 blood donors: 20 women (40%) and 30 men (60%) in
age 15-68 yrs.
Results: The statistical analysis showed a correlation between the ARA
serum levels and intraocular inflammation intensity. High correlation was found in first
control between serum ARA level and the degree of vitreous inflammation and the presence
of fresh vessels sheathing, characteristic for retinal vasculitis. In next three controls,
this correlation was still present, but only in a case of vitreous changes. And at the end
of observation no correlation was found, neither between serum ARA levels and the activity
of vitreous inflammation, nor between the ARA levels and retinal vasculitis intensity.
Conclusions: The assessment of serum ARA in patients with idiopathic
posterior uveitis can act as an indicator for intraocular inflammation intensity and can
reflect the retinal autoimmunity. |
| Słowa kluczowe: |
endogenne zapalenie błony naczyniowej, przeciwciała
przeciwsiatkówkowe, system oceny zapalenia błony naczyniowej. |
| Key words: |
endogenous uveitis, antiretinal antibodies, uveitis scoring
system. |
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