NR 3-4/2002
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Wpływ monocytów na wczesną aktywację
limfocytów T u dzieci z idiopatycznym zapaleniem błony naczyniowej
The effect of monocytes on early activation of
lymphocytes T among children with idiopathic uveitis
Alina Bakunowicz-Łazarczyk, Tadeusz Moniuszko, Dorota Średzińska-Kita,
Małgorzata Mrugacz
Z Kliniki Okulistyki Dziecięcej Samodzielnego Publicznego Dziecięcego Szpitala
Klinicznego Akademii Medycznej w Białymstoku
Kierownik: prof. dr hab. n. med. Alina Bakunowicz-Łazarczyk |
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| Summary: |
Purpose: We have investigated T Lymphocytes
ability for CD69 molecule induction in presence and absence of monocytes in idiopathic
uveitis.
Material and methods: Twenty-five children with idiopathic uveitis were
studied. The control group consisted of 12 healthy children. Peripheral blood mononuclear
cells (PBMCs) were isolated from heparinised venous blood, by density gradient
centrifugation. CD69 expression was cytometrically assessed on freshly isolated and
cultured T lymphocytes.
Results: CD69 expression on freshly isolated peripheral blood T
lymphocytes was low in both studied groups. LPS-stimulated monocytes added to cultures of
T lymphocytes induced increase in CD69 expression but significantly lower in children with
idiopathic uveitis compare to healthy children. |
| Słowa kluczowe: |
monocyty, CD69, limfocyty T, idiopatyczne zapalenie błony
naczyniowej. |
| Key words: |
monocytes, CD69, T lymphocytes, idiopathic uveitis. |
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