NR 3-4/2002
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Terapia fotodynamiczna w starczym zwyrodnieniu
plamki - obserwacja roczna
Photodynamic therapy in age-related macular
degeneration - results of one year of observation
Halina Wykrota, Ariadna Gierek-Łapińska
Z I Kliniki Okulistyki ¦l±skiej Akademii Medycznej w Katowicach
Kierownik: prof. dr hab. n. med. Ariadna Gierek-Łapińska |
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| Summary: |
Purpose: To evaluate the efficacy of
photodynamic therapy (PDT) with verteporfin in reducing the vision loss and progression of
choroidal neovascularization (CNV) in patients with subfoveal CNV due to age-related
macular degeneration (AMD).
Materials and methods: 46 eyes of 46 patients with subfoveal,
predominantly classic CNV caused by AMD and best-corrected visual acuity of 5/50 to 5/10
were treated with photodynamic terapy with verteporfin (Visudyne, CIBA Vision).
Verteporfin was administered via intravenous infusion over 10 minutes. Fifteen minutes
after the start of the infusion, a diode laser light at 689 nm (Opal Photoactivator,
Coherent) was delivered over 83 seconds. Visual acuity and fluorescein angiography were
performed before and after the treatment at 7 days and 1, 3, 6, 9 and 12 months after the
initial - treatment. Retreatment in the same manner was applied if at follow-up
examination fluorescein leakage from CNV was seen. Outcomes were compared with those of
control group which consisted of 38 eyes of 38 patients of the same condition of the
disease, not treated with any method.
Results: The lost of visual acuity was significantly reduced in the
verteporfin - treated eyes compared - with controls. At the 12 month 73,91% eyes of PDT
group versus 36,84% of control group (p<0.001) lost fewer than 3 Snellen lines. The
vision loss appeared to be more rapid in first 6 months of the study.
During the study growth of CNV was diminished in PDT group compared with control group.
Conclusions: Results show, that photodynamic therapy may be an effective
method of treatment for predominantly classic subfoveal choroidal neovascularization
caused by AMD. Further studies are needed to find the best modes of PDT procedure. |
| Słowa kluczowe: |
starcze zwyrodnienie plamki, neowaskularyzacja podsiatkówkowa,
terapia fotodynamiczna, verteporfina. |
| Key words: |
age-related macular degeneration, choroidal
neovascularization, photodynamic therapy, verteporfin. |
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