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NR. 1/2007
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Wyniki długotrwałych
badań klinicznych: porównanie trzyletniego okresu użytkowania
silikonowo-hydrożelowych soczewek kontaktowych (lotrafilcon A) w
trybie przedłużonym do 30 dni i nocy oraz soczewek hydrożelowych
o niskiej tlenoprzepuszczalności noszonych w trybie dziennym
Long-term Clinical Results:
3 Years of Up to 30-Night Continuous Wear of Lotrafilcon A
Silicone Hydrogel and Daily Wear of Low-Dk/t Hydrogel Lenses
Peter Bergenske, O.D., Bill Long, B.S.,
Sally Dillehay, O.D., Ed. D, Joseph T. Barr, O.D., M.S.,
Peter Donshik, M.D., Glenda Secor, O.D., John Yoakum, O.D.,
Robin L. Chalmers, O.D. |
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| Summary: |
Purpose. To
summarize results of a 3-year clinical trial assessing
subjective and objective experience with lotrafilcon A
silicone hydrogel (SH) lenses for up to 30 nights of
continuous wear or low-Dk/t daily-wear (LDW) hydrogel
lenses. Methods. Nineteen sites dispensed SH lenses to
317 subjects (286 current wearers and 31 new wearers)
and 2-week replacement LDW lenses to 81 new wearers in a
3-year study. Results. For the SH cohort, limbal redness,
conjunctival redness, and corneal neovascularization
improved among 23%, 21%, and 13% of eyes, respectively
(P0.001), with no signs increasing significantly. For
the LDW cohort, limbal redness, papillary conjunctivitis,
and corneal staining increased among 11%, 21%, and 13%
of eyes, respectively (P0.02), with no signs improving
significantly. The change in average spherical
equivalent power was -0.03 diopters for the age-matched
SH cohort and -0.40 diopters for the LDW cohort
(P0.007). During the 3 years, the SH group reported
significantly less frequent dryness during and at the
end of the day, redness, photophobia, lens awareness,
and blurred vision. Significantly more LDW lens wearers
reported frequent during-the-day and end-of-day dryness
and blurred vision. Conclusions. During the 3 years,
lotrafilcon A lens wearers who wore their lenses
continuously for up to 30 nights showed stable,
long-term improvements in many signs of corneal health
and symptoms along with less myopic progression versus
daily wearers of low-Dk/t hydrogel lenses. Many
biomicroscopy signs and symptoms worsened among
neophytes wearing daily-wear low-Dk/t hydrogel lenses.
The use of lotrafilcon A lenses may minimize many ocular
changes from soft contact lens wear. |
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| Key words: |
Silicone hydrogel lenses,
Lotrafilcon A, Continuous wear, Myopic progression,
Biomicroscopy signs, Symptoms. |
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